Exendin-4 (Heloderma suspectum) – EIA Kit, CE Mark Certified

The Exendin-4 (Heloderma suspectum) – EIA Kit, CE Mark Certified (Catalog #EK-070-94CE) is a research reagent supplied by Phoenix Peptide under our specialized ELISA Kits – Assay Kits – RIA Kits category. This item is offered at a regular price of $645 for a package size of 96 wells.

Storage, Handling & Operational Notes

Transport & Regulatory Notes: To reduce background noise for this kit, do not add EDTA to your samples.Heparin can be used as an alternative to EDTA for this kit.

References & Citations: Links to publications that use this kit: C-terminal site-specific PEGylated Exendin-4 analog: A long-acting glucagon like Peptide-1 receptor agonist, on glycemic control and beta cell function in diabetic db/db mice. Tang D, Tian H, Wu J, et al. J Pharmacol Sci. 2018138(1):23-30. GLP-1 receptor agonists stimulate ANGPTL8 production through the PI3K/Akt pathway in a GLP-1 receptor-dependent manner. Liu J, Yang K, Xiao W, et al. Peptides. 2018106:83-90. The use of low molecular weight protamine to enhance oral absorption of exenatide. Zhang L, Shi Y, Song Y, et al. Int J Pharm. 2018547(1-2):265-273. Replacement of the C-terminal Trp-cage of exendin-4 with a fatty acid improves therapeutic utility. Lee JG, Ryu JH, Kim SM, et al. Biochem Pharmacol. 2018151:59-68. Sustained-release study on Exenatide loaded into mesoporous silica nanoparticles: in vitro characterization and in vivo evaluation. Chen C, Zheng H, Xu J, Shi X, Li F, Wang X. Daru. 201725(1):20. In vitro and in vivo characterization of a novel long-acting GLP-1 receptor agonist, exendin-4–Fc fusion protein Lian Lu, Xiaoqing Su, Yantai Wang et al., RSC Adv., 2017,7, 54178-54187 An approach for half-life extension and activity preservation of an anti-diabetic peptide drug based on genetic fusion with an albumin-binding aptide. Kim D, Jeon H, Ahn S, Choi WI, Kim S, Jon S. J Control Release. 2017256:114-120. Pyung-Hwan Kim, Minhyung Lee, Sung Wan Kim, Delivery of two-step transcription amplification exendin-4 plasmid system with arginine-grafted bioreducible polymer in type 2 diabetes animal model. J Control Release. 2012 Aug 20162(1):9-18. doi: 10.1016/j.jconrel.2012.06.010. Epub 2012 Jun 15. Di pasquale G, Dicembrini I, Raimondi L, et al. Sustained exendin-4 secretion through gene therapy targeting salivary glands in two different rodent models of obesity/type 2 diabetes. PLoS ONE. 20127(7):e40074. Nian Gong et al., Site-specific PEGylation of exenatide analogues markedly improved their glucoregulatory activity Br J Pharmacol. 2011 May 163(2): 399–412. Wei Gao et al., Pharmacokinetic and Pharmacodynamic Modeling of Exendin-4 in Type 2 Diabetic Goto-Kakizaki Rats J Pharmacol Exp Ther. 2011 March 336(3): 881–890. doi: 10.1124/jpet.110.175752 Su Young Chaea, Cheng-Hao Jin et al., Biochemical, pharmaceutical and therapeutic properties of long-acting lithocholic acid derivatized exendin-4 analogs Journal of Controlled Release Volume 142, Issue 2, 3 March 2010, Pages 206–213 Kamei et al. Importance of intermolecular interaction on the improvement of intestinal therapeutic peptide/protein absorption using cell-penetrating peptides. J Control Release. 2009 Feb 27. [Epub ahead of print] Samson et al. Gene therapy for diabetes: metabolic effects of helper-dependent adenoviral exendin 4 expression in a diet-induced obesity mouse model. Mol Ther. 2008 Nov16(11):1805-12.

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Specification / Feature	Details
Catalog Number	EK-070-94CE
Quantity	96 wells
Category	ELISA Kits – Assay Kits – RIA Kits
Price / Unit	$645
Intra-Assay CV:	<10%
Inter-Assay CV:	<15%
Sensitivity:	0.08 ng/ml
Specificity:	Peptide %
Exendin-4 (Heloderma Suspectum)	100
Exendin-3 (9-39)-NH2	100
Exendin-4 (3-39)	100
Lixisenatide	100
Glucagon (Human, Rat, Mouse, Porcine, Bovine)	0
GLP-1 (7-36)-NH2 (Human, Rat, Mouse)	0
GLP-1 (7-37) (Human, Rat, Mouse)	0
GLP-2 (Human)	0
Oxyntomodulin (Human, Rat, Mouse)	0
Linear Range:	0.08 – 0.86 ng/ml