MSH, alpha (Human, Rat, Mouse) – RIA Kit

The MSH, alpha (Human, Rat, Mouse) – RIA Kit (Catalog #RK-043-01) is a research reagent supplied by Phoenix Peptide under our specialized ELISA Kits – Assay Kits – RIA Kits category. This item is offered at a regular price of $942 for a package size of 125 tubes.

Storage, Handling & Operational Notes

Transport & Regulatory Notes: This package conforms to the 49 CFR173.421 for expected radioactive material limited quantity, N.O.S. UN2910.

References & Citations: Dynamic modulation of prohormone convertase 2 (PC2)-mediated precursor processing by 7B2 protein: preferential effect on glucagon synthesis. Helwig M, Lee SN, Hwang JR, Ozawa A, Medrano JF, Lindberg I. J Biol Chem. 2011286(49):42504-13. Obese carboxypeptidase E knockout mice exhibit multiple defects in peptide hormone processing contributing to low bone mineral density. Cawley NX, Yanik T, Woronowicz A, Chang W, Marini JC, Loh YP. Am J Physiol Endocrinol Metab. 2010299(2):E189-97. AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons. Claret M, Smith MA, Batterham RL, et al. J Clin Invest. 2007117(8):2325-36. Lean rats with hypothalamic pro-opiomelanocortin overexpression exhibit greater diet-induced obesity and impaired central melanocortin responsiveness. Li G, Zhang Y, Cheng KY, Scarpace PJ. Diabetologia. 200750(7):1490-9. Melanocortin activation of nucleus of the solitary tract avoids anorectic tachyphylaxis and induces prolonged weight loss. Li G, Zhang Y, Rodrigues E, et al. Am J Physiol Endocrinol Metab. 2007293(1):E252-8. Plasma and hypothalamic peptide-hormone levels regulating somatotroph function and energy balance in fed and fasted states: a comparative study in four strains of rats. Kappeler L, Zizzari P, Grouselle D, Epelbaum J, Bluet-pajot MT. J Neuroendocrinol. 200416(12):980-8. Proopiomelanocortin-derived peptides in rat cerebrospinal fluid and hypothalamic extracts: evidence that secretion is regulated with respect to energy balance. Pritchard LE, Oliver RL, Mcloughlin JD, et al. Endocrinology. 2003144(3):760-6. Obliteration of alpha-melanocyte-stimulating hormone derived from POMC in pituitary and brains of PC2-deficient mice. Miller R, Aaron W, Toneff T, Vishnuvardhan D, Beinfeld MC, Hook VY. J Neurochem. 200386(3):556-63. ARC POMC mRNA and PVN alpha-MSH are lower in obese relative to lean zucker rats. Kim EM, O’hare E, Grace MK, Welch CC, Billington CJ, Levine AS. Brain Res. 2000862(1-2):11-6. STZ-induced diabetes decreases and insulin normalizes POMC mRNA in arcuate nucleus and pituitary in rats. Kim EM, Grace MK, Welch CC, Billington CJ, Levine AS. Am J Physiol. 1999276(5 Pt 2):R1320-6. Changes in hypothalamic agouti-related protein (AGRP), but not alpha-MSH or pro-opiomelanocortin concentrations in dietary-obese and food-restricted rats. Harrold JA, Williams G, Widdowson PS. Biochem Biophys Res Commun. 1999258(3):574-7.

Related Research Products & Support

For complementary laboratory workflows, explore related items in our catalog: INSL3 / RLF (Human) – EIA Kit, extraction-free, CE Mark Certified, INSL3 / RLF (Human) – EIA Kit, extraction-free, and Inhibin alpha-Subunit (1-32) (Porcine) – RIA Kit available through Phoenix Peptide. Guaranteed for quality assurance and analytical precision.

Specification / Feature	Details
Catalog Number	RK-043-01
Packaging	125 tubes
Category	ELISA Kits – Assay Kits – RIA Kits
Price / Unit	$942
Intra-Assay CV:	<10%
Inter-Assay CV:	<15%
Sensitivity:	82.8 pg/ml
Specificity:	Peptide %ty
a-MSH	100
b-MSH (Human)	0
g-MSH (Human)	0
ACTH (Human)	0
b-Endorphin (Human)	0
Met-Enkephalin	0
Standard Range:	10 – 1280 pg/ml
Radioactivity:	Each kit contains 1.5 µCi of Iodine 125.